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Accumulating evidence suggests an involvement of the immune system in the pathogenesis of multiple sclerosis. In particular, the role of T lymphocytes in the initiation, formation, and activity of this pathological process is well established. On the other hand, there are reports on activated macrophages and B cells, the origin of certain immunoglobulins, and it is possible that monocytes may play an important role in MS pathogenesis. It is possible that MS-associated autoantigens are localized on the surface of macrophages or their products. We studied the DNA of peripheral monocytes in 30 patients with multiple sclerosis and 60 matched controls. DNA was purified from peripheral blood monocytes using the method of Buettner et al. The results have shown a significant increase in the number of the clones of T cells (TCR) in the multiple sclerosis group, as compared to the control group. DNA rearrangements of the TCR were studied using two probes, TCR-beta and TCR-gamma, by means of Southern blot
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The Jaguars hosted the Cleveland Browns at EverBank Field Saturday afternoon, and the home team came out in a full turnout and was ready to play a game.
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