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How to Restore ARKit.rar
Go to Download folder.

Rename the downloaded file to ARKit.rar.

Extract the file using WinRAR.

Go to the extracted folder.

You’ll find a sample project file, which requires Xcode.

Open Xcode (3.2 – 8.4).

Launch Organizer.

Select Projects from the menu (1).

Select the project containing the sample project file that you downloaded (2).

Select Restore from the menu (3).

Select Restore and select the destination folder on your Mac (1).

Select OK (2) and then Finish (3).

Use Xcode to Open the app and build the app.

Molecular mechanisms underlying the antifolate sensitivity of metaphase lethal mutagenesis.
The coordination of DNA and chromosome mechanics with chromosome segregation is mediated by the mitotic checkpoint complex (MCC). This complex, consisting of checkpoint proteins Bub1, Bub3, BubR1, Mad1, and Mad2 in vertebrates, serves to safeguard the fidelity of chromosome segregation. We found that the antifolate trimethoprim (TMP) inhibits the MCC by inhibiting the binding of Bub3 with BUBR1 in metaphase and by blocking mitotic arrest associated with prolonged mitosis in the presence of spindle poisons. In vitro assays for the assembly of MCC and POLD3-induced DNA synthesis demonstrated that TMP inhibits the binding of Bub3 with BUBR1 by binding directly to Bub3 at a site distinct from Bub1 and BubR1 binding sites. Experiments with GTP analogues revealed that the inhibition of binding between Bub3 and BUBR1 by TMP is due to the impairment of GTP-dependent conformational changes of Bub3, but not of Bub1 and BubR1, required for the binding with BUBR1. GTP-dependent conformational changes of Bub3 are essential for its binding with Mad2, which is a component of the MCC. Our findings indicate that TMP specifically binds to Bub3, inhibiting the assembly of the MCC, thereby increasing the rate of chromosome segregation without affecting DNA replication.When I began blogging in 2009, many people were starting to use RSS/Atom feeds. Bloggers were excited about the idea, but when I told people what I did

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