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There are many other antimicrobial agents with cephalosporin activity approved in the United States, some of which are as clinically effective as cefixime (884,883). Cefixime appears to be an appropriate choice for the treatment of uncomplicated gonorrhea in some regions (871).
Clinical studies of cefixime in pregnancy and of single-dose therapy in childhood have been published. The safety and efficacy of single dose cefixime (13) has been evaluated as single dose therapy for streptococcal pharyngitis, meningococcal meningitis, and group A streptococcal tonsillitis. In these three studies, cefixime was well tolerated and provided effective treatment. Although Crixivan is also a recommended treatment for these conditions, no data exist on the safety of single-dose use in pregnancy or childhood.
Bis-acetyl valeryl salicylic acid (BAVA) (sulcal), a formulation of the active ingredients of salicylic acid and acetyl salicylic acid, is a bacteriostatic drug approved in France for the treatment of mild to moderate acne vulgaris. No controlled data on the efficacy of BAVA in other skin conditions are available; however, many physicians prescribe BAVA for the treatment of acne in people with serious or extensive disease. BAVA has been used in clinical trials for treatment of croup and moderately severe colds in children 1267,1328. BAVA is indicated for severe ulcerative colitis in patients with a moderate or severe course (1753).
Antibodies against T. pallidum may persist in the serum for years after apparent clinical cure of primary syphilis (566). One study of 6,113 persons found that 8% of persons with primary syphilis who had a nontreponemal test positive at 6-month follow-up still had a positive nontreponemal test at 2 years post treatment (609). In a population-based study in Kansas, however, less than 1% of nontreponemal test positive persons had persistent nontreponemal test positivity at 18 months post treatment (610). Further studies are needed to evaluate potential long-term complications of syphilis.
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Kunio Takahashi. Masaru Tanaka. Shinsuke Izaki. Shigeru Kuboyama. Toshitaka Sato. All of them were killed by a bottle of poisonous gas. Papers regarding clinical chemistry and biochemistry. 3. Papers regarding clinical chemistry and. 21 Oncological Research; 1.Clinical and Experimental Pharmacology; 2.Oncology; 3.Clinical Pharmacology; 4.Cutaneous Surgery.
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