Principles Of Development 4th Edition Wolpert Pdf Free

chapter 8 considers the nematode and the sea urchin as models for the study of the development of the germ line. the nematode, which has a very short germ line, is used to provide an example of the way that the germ line develops from a single cell. the sea urchin is used to compare the developmental mechanisms in embryos with those in adults. this is the first chapter to cover the evolution of development.

chapter 9 considers the ways in which the brain develops in mammals. this chapter also describes the methods used to follow the development of the mammalian brain, both in the embryo and in the adult. it describes in detail the large amount of work on mouse and human embryonic and fetal development that has been done in this field.

chapter 10 describes the structure of the mammalian placenta, the most complex example of a secondary organ in the developing embryo. it considers how the structure of the placenta develops in the early embryo, and what happens to it after birth. the most complex function of the placenta is to supply the fetus with the oxygen and nutrients it needs for the very early stages of development, so that these can be used for the embryo to develop.

chapter 11 describes the development of the nervous system and the ways in which it develops in humans. it considers in turn the structures of the brain and spinal cord, and the ways in which they develop from the embryo, and the various ways in which they are conserved across evolution. the chapter also considers in detail how the nervous system develops in the mouse.

chapter 12 describes the ways in which the different tissues of the body, such as the heart and the skin, develop. these chapters consider the development of the specific tissues in the adult, and how these change as the adult is replaced by the fetus in the first stages of development.

the aim of the authors has been to provide a well-written, and thoroughly illustrated, introduction to the main principles of developmental biology. the book has been written by distinguished scientists, and should prove to be an invaluable resource for all those who study developmental biology. this book is an excellent guide for students at all levels and for researchers who wish to learn more about the principles of developmental biology. the authors have written the book in an engaging and clear style, and with the aid of figures and diagrams make the complicated subjects of developmental biology understandable.
i have been in the department of zoology at the university of oxford for more than 40 years, and have been a member of the faculty since 1981. i have been a member of the current science group since the beginning, and have been the current group leader since 1994. my particular research interests are in the field of the development and evolution of animal morphology, and i am particularly interested in the evolution of the external form of animals.
chapter 6 examines the mechanisms underlying the specification of cell types. in many species, this is determined by the action of extracellular signals from adjacent cells. in the early embryo of the frog xenopus, gastrulation is induced by the activity of the extracellular matrix (ecm), which is partly generated by cells. however, there is another mode of patterning, and we describe the mechanism of morphogenetic furrow formation in frog embryos. some of the classic experiments on frog gastrulation were performed by the developmental biologist hans spemann (who was a student of max perutz), and this chapter describes the results of experiments using transgenic frog lines expressing a gata4 construct. we also consider how cell types are specified in the chick and mouse embryos.
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