Waves MaxxWave for iPhoneÂ . Create a video slideshow, blank screen (with sound) and a motion wall. Each video can be different, or the same.A systematic review of the effect of common medication therapies on the rate of seizures in people with epilepsy.
The medical management of epilepsy is guided by the AED therapy algorithm, which has been developed and updated through clinical trials. The current review seeks to establish how close to the evidence base a given medication is, not simply by calculating the percentage of trials that showed efficacy, but by establishing the extent to which, and type of patients, that can be used to design and conduct trials to further contribute to improvements in AED therapy. The data for the review were identified through standard strategies and, specifically, through systematic searches of all English language publications from 1966 to 2007. This review addresses two issues: (i) the proportion of trials which showed efficacy in population groups versus the proportion of clinical trials which were undertaken in those groups; and (ii) the extent to which the treatment population characteristics in non-randomized studies were comparable to those with a randomized trial. The reviewed clinical trials are more likely to show efficacy in people with generalized tonic-clonic seizures than in people with partial seizures. Commonly used AEDs are effective in both, but only propranolol is statistically more effective for generalized tonic-clonic than partial seizures. The trial populations were strikingly similar, suggesting that non-randomized studies provide a good guide for prescribing. Results of further trials and systematic reviews are needed to update current recommendations and provide guidelines for the use of AEDs. FILED
DEC 08 2009